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Anti-Infectives

Click the product names to view Prescribing Information for TENKASI® (oritavancin)QUOFENIX®(delafloxacin) and VABOREM®(meropenem/vaborbactam)

Oral and IV option for MRSA and Pseudomonas aeruginosa1–3

Indicated for the treatment of the following infections in adults:1,2

  • acute bacterial skin and skin structure infections (ABSSSI)
  • community-acquired pneumonia (CAP)

Because of the risk of prolonged, disabling and potentially irreversible serious adverse drug reactions this product must only be prescribed when other antibiotics that are commonly recommended for these infections are inappropriate.1-2

Situations where other antibiotics are considered to be inappropriate are where:

  • there is resistance to other first-line antibiotics recommended for the infection
  • other first-line antibiotics are contraindicated in an individual patient
  • other first-line antibiotics have caused side effects requiring treatment to be stopped
  • treatment with other first-line antibiotics has failed

Consideration should be given to official guidance on the appropriate use of antibacterial agents.4

For carbapenem-resistant GNB infections - optimised for the treatment of KPC-CRE4–8

Indicated in adults for the treatment of:4

  • Complicated urinary tract infection (cUTI), including pyelonephritis
  • Complicated intra-abdominal infection (cIAI)
  • Hospital-acquired pneumonia (HAP), including ventilator-associated pneumonia (VAP)
  • Patients with bacteraemia that occurs in association with, or is suspected to be associated with, any of the infections listed above
  • Infections due to aerobic Gram-negative organisms with limited treatment options

Consideration should be given to official guidance on the appropriate use of antibacterial agents.4

A single-dose lipoglycopeptide with in vitro activity against MRSA and VRE*9–10

Indicated in adults and paediatric patients aged 3 months and older for the treatment of:9

  • Acute bacterial skin and skin structure infections (ABSSSI)

Consideration should be given to official guidance on the appropriate use of antibacterial agents.9

*In vitro activity does not necessarily infer clinical effectiveness.

Anti-infective webinars

Menarini are supporting ongoing education for HCPs. Please explore our on-demand anti-infective webinars.

Antimicrobial resistance and the role of stewardship

Menarini is committed to the fight against AMR by providing effective and innovative solutions to treat resistant infections. Menarini also supports the responsible use of antibiotics aligned to best practice in AMS.

Abbreviations
AMR, antimicrobial resistance; AMS, antimicrobial stewardship; CRE, carbapenem-resistant Enterobacterales; GNB, Gram-negative bacteria; IV,  intravenous; KPC, Klebsiella pneumoniae carbapenemase; MRSA, methicillin-resistant Staphylococcus aureus; VRE, vancomycin-resistant enterococci.

References:

  1. QUOFENIX 450 mg tablets SmPC.
  2. QUOFENIX 300 mg powder for concentrate for solution for infusion SmPC.
  3. Giordano PA et al. Clin Infect Dis 2019; 68(Suppl 3): S223–S232.
  4. VABOREM 1g/1g powder for concentrate for solution for infusion SmPC.
  5. Hecker SJ et al. J Med Chem 2015; 58: 3682–3692.
  6. Dhillon S. Drugs 2018; 78: 1259–1270.
  7. Toussaint KA et al. Ann Pharmacother 2015; 49: 86–98.
  8. Pogue JM et al. Clin Infect Dis 2019; 68: 519–524.
  9. TENKASI 400 mg powder for concentrate for solution for infusion SmPC.
  10. Brade KD et al. Infect Dis Ther 2016; 5: 1–15.

Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. Adverse events should also be reported to A. Menarini Farmaceutica Internazionale SRL. Phone 0800 085 8678 or email: [email protected]

These medicinal products are subject to additional monitoring.

PP-AI-UK-0471 February 2024

Adverse events should be reported. Reporting forms and information can be found at www.yellowcard.mhra.gov.uk or search for MHRA Yellow Card in Google Play or Apple App Store.

Adverse events should also be reported to A. Menarini Farmaceutica Internazionale SRL.

Phone 0800 085 8678